PENINGKATAN SISTEM IMUN OLEH KOMBINASI EKSTRAK ETANOL DAUN AWAR – AWAR (Ficus septica burm. F) DAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera) SEBAGAI KO-KEMOTERAPI KANKER PADA TIKUS PUTIH BETINA GALUR SPRAGUE DAWLEY YANG DIINDUKSI DOKSORUBISIN

Abstract

Use of the drug doxorubicin for cancer therapy causes decreasing of immune system reported. Leaves of Ficus septica Burm. F and leaves of Moringa oleifera as immunostimulatory agents. The purpose of this study, among others, determine the combined effects of ethanol extract of Ficus septica Burm. F leaves and ethanol extract of Moringa oleifera leaves as co-chemotherapy for in female rats Sprague Dawley strain induced doxorubicin. Eighteen Sprague Dawley rats were divided into six treatment groups, normal group was given 0.9% NaCl 10ml / kgBB, positive control group were given by doxorubicin with dose of 4.67 mg / kgBB, single-dose treatment group were each given ethanol extract of Ficus septica Burm F leaves dose of 750 mg / kgBB and ethanol extract of Moringa oleifera leaves 500 mg / kgBB, treatment groups were given by combination of ethanol extract Ficus septica Burm. F leaves and Moringa oleifera leaves with a dose of 1.25 g / kgBB and a dose of 1 , 75 g / kgBB. treatment carried out for 7 days. On days 1 and 4 of each treatment groups except the normal group induced by doxorubicin 4.67 mg / kgBB intramuscularly. Blood sampling performed on day 0 and 7 th for lymphocytes CD3+ and lymphocytes CD8+ test. The results showed that the combination of ethanol extract Ficus septica burm. F leaves and Moringa oleifera leaves dose of 1.25 g / kgBB and the dose of 1.75 g / kgBB can enhanched immune system relative small which was not statistically significantly different (p> 0.05). However, a single dose of ethanol extract Moringa oleifera leaves dose of 500 mg/kg have immunostimulatory activity as lymphocytes CD3+ and lymphocytes CD8+ were more effective than a single dose of ethanol extract of Ficus septica Burm. F leaves dose of 750 mg/kgBB.